What is the record for the largest point differential in an NFL game?

73 points.

1940- Chicago Bears shut out the Redskins 73-0.

What is the record for the largest point differential in an NFL game?pro basketball

Sad to say it was the 1940 Bears over the Redskins 73-0 it was for the NFL Championship. The Redkskins did bet the Giants 72-41 as mentioned earlier.

What is the record for the largest point differential in an NFL game?nba history ,nba teams

73 points
these answers are incorrect.

the most points scored in a game was 72 by Washington agianst Giants 1966.

the most points in a **** out was

64 points for Philadelphia vs. Cincinnati, Nov. 6, 1934

(After I posted I see that the Chicago Bears history page says that they beat Washington 73-0 in 1940. I do not know why the NFL Factbook and Chicago differ. Perhaps the NFL started keeping track after 1940? But one of the sources is wrong.)
It was 73-0 in the NFL Championship of 1940; Chicago over Washington. I am avid reader of stats, especially football records. Also, I had a friend that actually played in that game. He told me that one of the Redskin's best receivers broke his ribs after he nearly caught a touchdown pass. He played in the NFL for ten seasons. He also was a pro softball fast pitch pitcher. His name was Leroy Zimmerman.